Genetic Syndromes & Gene Therapy is an official peer-reviewed journal for the rapid publication of innovative research covering all aspects of Gene Mapping and Gene Therapy. Genetic Syndromes, Gene Mapping & Gene Therapy with highest impac ...
A growing body of evidence supports the critical role of parent interactions in developmental outcomes for children with Down syndrome. Parents who demonstrate more interactions that are responsive (i.e., sensitive to child cues) te ...
Down Syndrome (DS), or trisomy 21, occurs in one out of 700-1000 live births. It is commonly observed that DS patients present obesity and zinc deficiency. Zinc deficiency could be related to overactivity of the enzyme Cu/Zn Superoxide Dismutase ( ...
Coccidiomycosis is a common cause of fungal infections in non-compromised and immuno compromised patients, which is endemic to the Southwest United States, Northern Mexico and parts of New Mexico. It causes approximately 100,000 infections per yea ...
Coccidioidomycosis is a dimorphic fungus endemic to the southwestern United States, Central and South America. We report a case of a previously healthy person who presented with respiratory failure and disseminated Coccidioidomycosis who eventuall ...
Coccidioidomycosis is a fungal disease found only in the Western Hemisphere. It is caused by two nearly identical species, Coccidioides immitis and C. posadasii, generically referred to as the “Californian” and “no ...
Research on gene expression (GE) provides insights into the physiology of a cell or group of cells at a given point in time. Studies of changes in GE can be used to identify patients at higher risk for various medical conditions, a higher symptom ...
The DNA in a cell is usually wrapped around proteins called histones, which are packed tightly together to form a structure called chromatin . The main purpose of histones is to condense DNA and to regulate chromatin (and, therefore, to influence ...
The evolution of multicellular organisms from simple, single-cell organisms was a pivotal turning point in the history of life. Many different lineages of organisms, including animals, independently evolved multicellularity. One advantage of multi ...
The three-dimensional folding of DNA is the final context that allows for gene transcription to initiate. The folding of DNA into higher order structures is not a random event, and it has long been thought to affect gene transcription. At the nucl ...
The binding of (core) transcription factors critically depends on the recognition of specific DNA sequences, known as DNA motifs. High throughput techniques, such as ChIP-seq and enhanced yeast one-hybrid, which visualizes the interaction of a tra ...
Gene expression regulation in eukaryotes includes interactions between promoters and enhancers, but our understanding of the mechanisms that drive these interactions, or that determine their specificity, is far from complete. At the basis of trans ...
Transcriptional regulation of eukaryotic genes has classically been viewed as the interaction of elements in the immediate vicinity of the transcription start site (promoters) with upstream elements (enhancers) . Mutations in conserved upstream pr ...
Guideline of quality articulation, or quality regulation, incorporates a wide scope of systems that are utilized by cells to increment or abatement the creation of explicit quality items (protein or RNA). Advanced projects of quality articulation ...
Chromatin regulation is understood to be one of the fundamental modes of gene regulation in eukaryotic cells. We argue that the basic proteins that determine the chromatin architecture constitute an evolutionary ancient layer of transcriptional re ...
McCune-Albright syndrome (MAS) is a rare, genetic, non-inherited condition that causes bone tumors, bone deformity and fractures. The manifestations include polyostotic fibrous dysplasia, café au lait spots, and precocious puberty.Mutation ...
Genes are so embedded in our intellectual DNA (to repatriate a fashionable idiom) that we tend to forget that we still have no agreed definition of the term . When we say that there are fewer than 25,000 genes in the human genome , we are thinking ...
Nitrogen fertilization is the process that is most effectively used as part of a balanced fertilization plan that aims to maximize economic return and maintain environmental quality. This describes the specific benefits of nitrogen fertilization a ...
Nitrogen is considered to be the most important nutrient, and plants absorb more nitrogen than any other element. Nitrogen is essential to in making sure plants are healthy as they develop and nutritious to eat after they& ...
Nitrogen fertilization is the process that is most effectively used as part of a balanced fertilization plan that aims to maximize economic return and maintain environmental quality. This describes the specific benefits of nitrogen fertilization a ...