Wound is a type of injury happened quickly when skin is cut, open, or where blunt force trauma causes a contusion. In pathology, it specifically refers to a sharp injury which damages the dermis of the skin. Micro-organisms, i.e., bacteria or fungi are found on wounds. They rapidly infect the skin to seriously impeding wound healing process. Bacterial biofilms delayed wound healing of chronic wounds by competing nutrients and oxygen of the body. Increased in wound size, wound hypoxia, and vessels occlusion delayed the wound healing. A bacterial population size of 105 colony forming units (cfu)/g or cm2 indicates an infected wound and 104cfu/g or cm2 in complex wounds.
On the basis of condition wound could be divide in to two types: one is chronic wounds and other is burn wound and sepsis. Wound healing is specific biological process related to the general phenomenon of growth and tissue regeneration. The entire process of wound healing is ordered cascade of events, which can be divided into four distant but over lapping phase of homeostasis, inflammation, proliferation and maturation.