Vitiligo is a disease that causes the loss of skin color in blotches. The extent and rate of color loss from vitiligo is unpredictable. It affect the skin on any part of your body, hair, inside of the mouth and even the eyes.Vitiligo occurs when the cells that produce melanin die or stop functioning. Vitiligo affects people of all skin types. The main sign of vitiligo is color (pigment) loss that produces light or white patches on your skin. Usually, the discoloration first shows on sun-exposed areas, such as the hands, feet, arms, face and lips. Vitiligo signs include skin discoloration, premature whitening or graying of the hair on your scalp, eyelashes, eyebrows or beard, loss of color in the tissues that line the inside of your mouth and nose, loss of or change in color of the inner layer of the retina, discolored patches around the armpits, navel, genitals and rectum. Depending on the type of vitiligo, the discolored patches may cover in many parts of your body, only one side or part of your body and one or only a few areas of your body. Vitiligo may be caused due to Family history, disorder in which your immune system attacks and destroys the melanocytes in the skin or a trigger event, such as sunburn, stress or exposure to industrial chemicals Open access to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. There are two parallel �roads� towards open access: Open Access articles and self-archiving. Open Access articles are immediately, freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is �self-archiving� (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals. Open Access raises practical and policy questions for scholars, publishers, funders, and policymakers alike, including what the return on investment is when paying an article processing fee to publish in an Open Access articles, or whether investments into institutional repositories should be made and whether self-archiving should be made mandatory, as contemplated by some funders.