It is defined as a clinical condition which is characterized by widening of blood vessels due to excess relaxation of muscular wall of the vessels. The medicine that causes dilation of blood vessels is known as vasodilators. Generally vasodilators are given to decrease the blood pressure. It openly affects the connection between mean arterial pressure, cardiac output and total peripheral resistance.Peer review refers to the work done during the screening of submitted manuscripts and funding applications. This process encourages authors to meet the accepted standards of their discipline and reduces the dissemination of irrelevant findings, unwarranted claims, unacceptable interpretations, and personal views. Publications that have not undergone peer review are likely to be regarded with suspicion by academic scholars and professionals.