It is a type of cardiovascular diseases which affects the blood vessels. It is a clinical condition of large and medium sized arteries which is affected by dysfunction of endothelial cell. Pathogens, cytokines, inflammatory stimuli endothelial cells are factors which causes vascular diseases. Once endothelial cells become activated it release cytokines and chemokines which expresses adhesion molecules on their surface which results in to release of WBC. WBC can infiltrate the blood vessels wall. Stimulation of smooth muscle layer with cytokine further causes thickening of vessel wall and at a final stage it results in to strokes.Scholarly peer review is the process of subjecting an author'sscholarlywork, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal.