The traditional applications of biotechnology/bioprocessing are mostly in the area of food, bakery products, alcoholic beverage, which are still important up to this date. The commercial success of production of the penicillin lead to the ideal and contamination-free environment bioprocessing and the advance to genetic engineering of microbial, animal and plant cells to produce recombinant proteins or metabolites. Vistas in recombinant DNA techniques, gene manipulation, cell fusion and tissue culture make micro batch reactors no longer hindrance. However, the scale-up technique to translate a scientific invention into commercial reality is not that easy as yet due to the complexity of biological systems and hardship in control. If utilization of mathematical modeling of the rate of cell growth, product formation and substrate uptake, and vigorous evaluations and monitoring of various process parameters in aseptic environmental conditions may bring pilot-scale step may be completed successfully, then the industrial-scale operations commences. This aim of this presentation is to enlighten biotechnologists with some engineering disciplines and to enable the communication on a professional level with bioprocess engineers in both upstream and downstream technologies within the given presentation time. In upstream technology, different reactors (batch reactor, continuous reactors, fed-batch/semi-batch reactors, fluidized bed reactor, immobilized cell bioreactors, airlift reactor), media design, and mixing will be elucidated. In downstream processing operations (also known as unit operations) involve using adsorption, centrifugation, chromatography, crystallization, drying, evaporation, filtration, flocculation, homogenization, microfiltration, milling, precipitation, sedimentation, solvent extraction and ultrafiltration for cell removal, cell disruption, cell debris removal, primary isolation, product enrichment and final isolation and treatment of effluents .Each open access journal delivers the latest updates in the respected research area in various formats so that subscribers can access the same through various options. With the growing number of scientific enthusiasts and readers by a large margin, the efficacy of open access publishing has witnessed an assertive impact. The importance of Peer-reviewed open access journals has also grown in modern learning environment as most of the students need a swift and instant access to published research work free of cost. Most of the open access journal articles can be cited with proper reference, which boosts the prospects of research. Bioprocessing deals with the development and design of equipments and processes the manufacturing of products like feed, food, nutraceuticals, pharmaceuticals, chemicals, and polymers from biological materials. Bioprocess engineering from PrimeOA Publications having an open access journal named as Journal of Bioprocessing & Biotechniques which strives to release issues bimonthly and is adamant to publish new findings related to the field of Bioengineering. Bioprocess engineering related to the area of Bioprocess & Bioengineering, Food and Bioprocess Technology, Immobilization Biotechnology, Bioprocessing such as downstream, up-stream processing, bio reactors etc. This Journal of Bioprocessing & Biotechniques publishes the article like research, review, perspective, opinion or short commentaries, methodology, etc. based on the topics which relates this journal. This follows a peer reviewing process in publishing the articles. Open access articles are essentially peer-reviewed and available for access through the directory of Open Access journals.