Tumor necrosis is often limited to a small area within the sample. Its presence suggests a more aggressive breast cancer. Hypoxia is a marker of more aggressive tumors and tumor necrosis was significantly associated with features such as high histologic grade, vascular invasion by tumor cells and reduced survival. Tumor necrosis was defined as areas of necrotic tumor cells immediately adjacent to viable tumor tissue .Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse cellular events such as cell survival, proliferation, differentiation, and death. Characteristics of tumour cellSelf-sufficiency in growth signals,Insensitivity to anti-growth signals, Evading programmed cell death or Activating Invasion and Metastasis, Limitless replicative potential, Sustained angiogenesis, Tissue invasion and metastasis. A tumor is a mass or lump of tissue that may resemble swelling. Not all tumors are cancerous, but it is a good idea to see a doctor if one appears.Cancer cells grow and divide at an abnormally rapid rate, are poorly differentiated, and have abnormal membranes, cytoskeletal proteins, and morphology. The abnormality in cells can be progressive with a slow transition from normal cells to benign tumors to malignant tumors. Tumour necrosis factor (TNF), a naturally occurring protein that is produced in the human body by the phagocytic cells known as macrophages. The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. The tumor necrosis factor (TNF) superfamily, composed of 19 ligands and 29 receptors, plays highly diversified roles in the body.