The principle of an antitumoral response of the immune system in vivo has been recognized already about 100 years ago by the physician William B Coley.TNF is primarily produced as a type II transmembrane protein arranged in stable homotrimers. Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its ubiquitous receptor TNF receptor 1 (TNFR1). Aortic dissection is a medical emergency. Early diagnosis and treatment are important. Over time, the tear can affect your brain, lungs, arms, legs, and heart. This depends on where along your aorta the tear occurs. Acute aortic dissection can be treated surgically or medically. In surgical treatment, the area of the aorta with the intimal tear is usually resected and replaced with a Dacron graft. Emergency surgical correction is the preferred treatment for Stanford type A (DeBak Acute aortic dissection is the most common life-threatening disorder affecting the aorta.( type I and II) ascending aortic dissection. Although acute aortic dissection classically produces sudden onset of severe chest pain that often has a tearing or ripping quality, he goals of early management of aortic dissection are to control pain and limit the extension of the dissection using anti-impulse therapy. Acute aortic dissection (AAD) is associated with unacceptably high mortality rate.