Tumor necrosis is often limited to a small area within the sample. Its presence suggests a more aggressive breast cancer. Hypoxia is a marker of more aggressive tumors and tumor necrosis was significantly associated with features such as high histologic grade, vascular invasion by tumor cells and reduced survival. Tumor necrosis was defined as areas of necrotic tumor cells immediately adjacent to viable tumor tissue .Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse cellular events such as cell survival, proliferation, differentiation, and death. Aortic dissection is a tear that develops along the inner layer of the aorta. Blood spills through the inner layer tear and into the middle layers of the aorta. In surgery, damaged sections of the aorta are removed and a synthetic graft is often used to reconstruct the damaged vessel. The objective in the surgical management of aortic dissection is to remove the most severely damaged segments of the aorta, and to eliminate the entry of blood into the tear. About 20% of patients with aortic dissection die before reaching the hospital. Without treatment, mortality rate is 1 to 3%/hour during the first 24 hours, 30% at 1 week, 80% at 2 week, and 90% at 1 year. Hospital mortality rate for treated patients is about 30% for proximal dissection and 10% for distal.