Trypanosoma evansi is the cause of trypanosomiasis (Surra) which multiplies in the blood and body fluids of a camel. Based on author knowledge, the outbreak of trypanosomiasis has not been reported in Iran yet. Camels in Southern Fars province of Iran, suffering from mortalities and abortions, were examined clinically. Blood samples were prepared from affected camels. Haematologic indices were measured. Dead camels and aborted fetuses were necropsied and macroscopic findings were recorded. Sick animals were treated by Quinapyrmine sulfate (inject). Clinical signs such as weakness, lethargy, tachycardia, fever, pale mucosa, subcutaneous edema in brisket and eyelids, nasal and ocular discharges, and weight loss were observed. Here we describe an outbreak of trypanosomiasis in the South of Fars province of Iran.