the high complexity of transcriptional regulation is also derived from the involvement of non-coding RNAs (ncRNAs). Indeed, research over the last two decades has revealed new classes of ncRNAs, including microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), long ncRNAs (lncRNAs), circular RNAs (circRNAs), and enhancer RNAs (eRNAs), each with different regulatory functions and altogether belonging to a larger RNA communication network ultimately controlling the production of the final protein