Blood transfusions are generally necessary after an injury or surgery to a person which causes a high amount of blood loss. This enables management and investigation of any suspected transfusion related disease transmission or transfusion reaction. Transfusion therapy is a sickle-cell disease necessitates the use of blood transfusions in the management of acute cases and as a prophylaxis to prevent complications by decreasing the number of red blood cells (RBC) or by adding normal red blood cells. The chronic red blood cell transfusion therapy is very efficacious in children to some extent in reducing the risk when abnormalities increased in cerebral blood flow velocities. Journal of Blood Disorders & transfusion evolves scientific literatures from time to time in terms of specialization and target audience. Blood Disorders & transfusion covers the articles supporting this this transfusion therapy