Although transfusion of human blood can be life saving, it is not without risks. Transfusion-transmitted infections (TTI) can be transmitted through blood transfusions. The TTI problem is directly proportional to the prevalence of infections among blood donors. Hepatitis B virus (HBV), hepatitis C virus (HCV), Human immune deficiency virus (HIV) and syphilis are the most important lethal agents in TTIs. The incidence rates of these infections are hard to calculate due to the asymptomatic and the latent nature of these diseases. Blood safety presents a serious challenge in Egypt, having the highest recorded prevalence of HCV antibodies in the world. Prevalence of HCV was reported to be 13.9% among healthy populations. Adults have higher HCV prevalence (15.7%) than children (4.0%). Geographically, HCV prevailed more in the Nile delta (15.8%) than in Upper Egypt (9.02%). Safety of Blood Transfusion: