TLRs are a type of pattern recognition receptor (PRR) and recognize molecules that are broadly shared by pathogen but distinguishable from host molecules, collectively referred to as pathogen-associatd molecular patterns (PAMPs). Functions of the clotting cascade during inflammation include what? ... What role do toll-like receptors (TLRs) play in inflammation? >TLRs increase cellular resistance and lymphocyte response to invasion. *TLRs are located on many white blood cells and can recognize a variety of pathogens.