Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain. Tau pathology concerns many familial or sporadic neurodegenerative disorders, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), FTDP-17, myotonic dystrophy (MyoD), and many other diseases. Tau pathology is suspected to accumulate first in the Lateral Entorhinal Cortex (LEC) and then spread to other sites in the medial temporal lobe, such as the perirhinal cortex, as well as neocortical sites such as the posterior cingulate cortex. High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.