A growing body of evidence supports the critical role of parent interactions in developmental outcomes for children with Down syndrome. Parents who demonstrate more interactions that are responsive (i.e., sensitive to child cues) tend to have children with Down syndrome who score higher in assessments of cognition, play competence, and language development. In fact, just the supportive presence of a mother has been found to elicit more engagement in play for children with Down syndrome. In contrast, parent directiveness has been found unrelated to developmental outcomes in some research and more troubling; in other research, more parental directiveness has been found to be associated with less developmentally competent outcomes for children with Down syndrome. Given the associations between parent interactions and child outcomes in Down syndrome, it is important to understand how these approaches might be used to improve developmental trajectories. In the next section, we review findings regarding parent-training interventions to improve parent–child interactions for this population.