Staphylococcus aureus is a Gram positive bacterium found as a commensal in humans. Nosocomial Staphylococcus aureus infections are of major concern because of their serious complications, like bacteremia (blood infection), endocarditis, osteomyelitis (bone infection), skin and soft tissue infections etc. The overall rate of mortality from Staphylococcalbacteremia ranges from 11 to 43 percent, primarily due to the emergence of antibiotic resistant strains. Staphylococcus aureus infections are now the most common cause for children being hospitalized for surgical drainage of pus, the most common cause of bacteremia in people over 65 years old, and the most serious cause of prosthetic device and intravascular line infection. Risk factors for infection include disruption of mucosal or cutaneous surfaces, introduction of foreign or medical device, surgery, hemodialysis or host immune suppression.