Questions have arisen recently about the role of spiritual well-being in strengthening the resilience of youth. To explore this association, this case study focused on the relationships and connectedness of young people who attend one religious organization as a means of enhancing their spiritual well-being. In line with the purposes of an instrumental case study, different sources of data (quantitative and qualitative) were collected on the phenomenon of interest—spiritual well-being. A theoretical purposive sample of 65 people participated in the study. A mixed methods research approach guided this case study, which incorporated both single- and multicase study techniques. Through an abductive analysis process, spiritual well-being and resilience were shown to be interrelated and ecologically bound. This mixed-methods case study presents one possible explanation for the often observed yet poorly understood relationship between spiritual well-being and positive youth outcomes, such as resilience.