This is an inherited anemic disease starts with the frontal bone, cheek bones, maxillary bone, short stature. These have very difficult diagnosis to newborns. These also include some surgery. These have subtypes in clinical treatments. These needs regular blood transfusions, iron chelating therapy. The most common includes are the bone marrow transplantation these are the most common medical treatments. Scholarly peer review is the process of subjecting an author's scholarly work, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal. The work may be accepted, considered acceptable with revisions, or rejected. Peer review requires a community of experts in a given (narrowly defined) field, who are qualified and able to perform reasonably impartial review