Rheumatoid arthritis and osteoarthritis speak to the two essential obsessive conditions that influence the joints and periarticular structures. In spite of the fact that the causes basic these conditions are very distinctive from one another, both conditions can cause extreme torment and deformation in different joints within the body. Pharmacological administration plays an vital part within the treatment of each clutter. Since physical advisors and other recovery masters regularly work with patients who have rheumatoid joint pain or osteoarthritis, an understanding of the sorts of drugs utilized to treat these infections is imperative. This chapter starts by portraying the etiology of rheumatoid joint malady and the pharmacological treatment of rheumatoid joint pain. An closely resembling talk of osteoarthritis takes after. These depictions ought to clarify medicate therapy's part in joint pain and the affect drugs can have on patients accepting physical treatment and word related treatment.