Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions including arthritis and "non-articular rheumatism", also known as "regional pain syndrome" or "soft tissue rheumatism". Rheumatoid arthritis (RA) is a common chronic immunologic and debilitating disease affecting about 0.5–1% of the population worldwide.1 It is a systemic disorder involving mainly the peripheral synovial joints in a symmetrical fashion and leads to the progressive destruction of the involved joints. Rheumatoid arthritis is a disease that affects 0.3 percent to 1.5 percent of the general population. Foot deformities are a major source of pain and disability. The frequency and degree of problems are directly related to the disease duration (i.e., the longer the disease, the greater the deformity). A typical patient with rheumatoid forefoot disease may have components of hallux valgus (bunion deformity), metatarsalgia (pain over the ball of foot with loss of fat pad) and hammertoe deformities. There may be painful thick callous areas under the ball of the foot or on the tops of the toes. Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. The open access journals are peer reviewed scholarly journals of Biochemical engineering. The top open access Biochemical engineering journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles.