With the development of new cancer therapies, systemic toxicity profile and effects on survival achieved an important improvement. However, a constellation of toxicities has emerged, even more remarkably, cutaneous adverse events. This report, developed by a board of Brazilian experts in oncodermatology, aims to establish a guideline for the dermatological care of oncologic patients. When possible, evidence-based recommendations were made, but in many cases, when strong evidence was not available, a consensus was reached, based on some data supporting therapies combined with personal experiences.A multidisciplinary team with a good interaction between the different specialists (e.g.: oncologists, dermatologists, nurses) is fundamental for the best supportive care for cancer patients and their families. Different societies and associations are dedicated to the research, support and education in all aspects of cancer treatment, such as the Multinational Association of Supportive Care in Cancer (MASCC), the American Society of Clinical Oncology (ASCO), the Oncology Nurse Society (ONS), and the National Comprehensive Cancer Network (NCCN).