"Journal of Biosensors & Bioelectronics is one of the open access journals. The journal is the best in providing and approaching the current research in the related field. The Journal provides the best information by accepting original research, review, clinical case reports. Quantum nanosensors are based on intrinsic resonances of metallic nanoparticles and semiconductor quantum dots. In this report, we propose ultra-sensitive sensors based on fundamentally different concepts and principles. In these sensors the rules of quantum mechanics are used to detect ultra-small variations of the refractive index of the environment