Psychoneuroimmunology (PNI) is a relatively incipient field of study that optically canvasses the interactions between your central nervous system (CNS) and your immune system. Researchers ken that our CNS and immune system can communicate with each other, but they only recently commenced to understand how they do it and what it signifies for our health. The nerves in your encephalon and spinal cord make up your CNS, while your immune system is composed of organs and cells that forfend your body against infection. Both systems engender minuscule molecules and proteins that can act as heralds between the two systems. In your CNS, these heralds include hormones and neurotransmitters. Your immune system, on the other hand, uses proteins called cytokines to communicate with your CNS. There plenty of subsisting research about the effects of accentuate on the immune system. Many of these studies fixate on the relinquishment of cytokines in replication to both physical and psychological stress. A cytokine is a diminutive protein that relinquished by cells, especially those in your immune system. There are many types of cytokines, but the ones that are generally stimulated by stress are called pro-inflammatory cytokines. Under mundane circumstances, your body releases pro-inflammatory cytokines in replication to an infection or injury to avail ravage germs or repair tissue. When you physically or emotionally stressed, your body additionally releases certain hormones, including epinephrine (adrenaline). These hormones can bind to categorical receptors that signal for the engenderment of pro-inflammatory cytokines. To increase the visibility and ease of use of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving services. Indexing provides easy access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal.