Propolis is a bee product which has shown antimicrobial, anti-inflammatory and immunomodulatory activity. It also stimulates wound-healing. Propolis has a lot of components, but also some allergens were identified. Propolis may induce allergy, mainly allergic contact dermatitis after topical application. It has been recognized as an occupational contact allergen, mainly in beekeepers but also in musicians and people who make stringed musical instruments Beekeepers are exposed to allergens from propolis more often than general population. Propolis allergy in beekeepers occur 0.76%-4.04%. There are some factors which may influence on the occurrence of propolis allergy in beekeepers. allergic reactions to propolis were reported from beekeepers, as well as musicians and artists that modulate figures with wax. The first case of allergic contact dermatitis after propolis was published in 1915 and described a beekeeper who had skin lesions on his hands. Since then, propolis is recognized as an occupational contact allergen mostly in beekeepers as they are an occupational group, the most exposed to allergens from propolis. Review of the world literature indicates that ¼ people allergic to propolis are beekeepers. Allergy to propolis is not a common phenomenon, but there are groups of greater risk of sensitization like beekeepers and their family members who are the most exposed to contact to propolis and its allergens.