Product recovery and purification, such as centrifugation, chromatography, crystallization, dialysis, drying, electrophoresis, filtration, precipitation, etc., are essential finishing steps to any commercial fermentation process. Because of complex fermentation broths and high-purity requirements for some products, large-scale fermentation studies often involve sophisticated downstream processing, which may account for up to 90% of the total production cost [161]. For instance, the separation of organic compounds is carried out at the industrial level using distillation, which consumes large amounts of energy [162]. To overcome the problem of product inhibition, several integrated fermentation/product recovery technologies have been investigated for solvent removal and have improved fermentation performance in the last decade