Transmissible spongiform encephalopathies (TSEs) are a gathering of dynamic, perpetually lethal, conditions that are related with prions and influence the cerebrum (encephalopathies) and sensory system of numerous creatures, including people, dairy cattle, and sheep. As per the most across the board theory, they are transmitted by prions, however some other information recommend a contribution of a Spiroplasma infection. Mental and physical capacities break down and numerous little gaps show up in the cortex making it seem like a wipe when mind tissue acquired at dissection is inspected under a magnifying instrument. The scatters cause impedance of cerebrum work, including memory changes, character changes and issues with development that exacerbate constantly.