"Elevated pressure extraction experiments were carried out using a home built pressure instrument. Samples were heated at 65–100°C under a constant pressure of 45,000 psi in stainless steel reaction vessel coupled to a manually operated HiP High Pressure Generator (High Pressure Equipment Company, Erie, PA, USA). This instrument uses a hydraulic screw pump to compress fluid in order to generate pressure. Since water is virtually non-compressible, in the event of a system failure, discharge forces are minimal and do not present a hazard to equipment or personnel. PrimeOA Publications International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society. PrimeOA Publications also organizing 3000+ International Scientific Conferences and events yearly all over the world with the support of 1000+ Scientific associations worldwide. Citation: Fowler CB, O’LearyTJ, MasonJT (2014) Improving the ProteomicAnalysis of Archival Tissue by Using Pressure-Assisted Protein Extraction:A Mechanistic Approach.J Proteomics Bioinform7: 151-157."