"A NEP 2320 Barocycler (Pressure Biosciences) modified by the manufacturer to hold isobaric pressure was also used to develop pressure-assisted extraction protocols. Pressure cycling technology, consisting of repeated cycles of high pressure to low pressure, has been used to recover proteins, lipids and nucleic acids from fresh tissue. Our laboratory group investigated using pressure cycling to augment protein recovery from FFPE tissue surrogates, but determined that static pressure and temperature over 65°C were move effective in reversing formaldehyde cross-links. PrimeOA Publications International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society. PrimeOA Publications also organizing 3000+ International Scientific Conferences and events yearly all over the world with the support of 1000+ Scientific associations worldwide. Citation: Fowler CB, O’LearyTJ, MasonJT (2014) Improving the ProteomicAnalysis of Archival Tissue by Using Pressure-Assisted Protein Extraction:A Mechanistic Approach.J Proteomics Bioinform7: 151-157."