Pistagremic acid (PA) is a bioactive tri-terpene isolated in total quantity from the galls of Pistacia integerrima. PA has been documented for a broad range of in vitro and in vivo biological properties. This letter documented the bioloigical potential of PA, which directed the researcher to re-isolate this compound and enhanced their biological potential. Graphical abstract showing Pistagremic acid (PA) as a broad spectrum natural inhibitor from Pistacia integerrima.