Pharmacokinetics may be defined as the study of the dynamic movements of foreign chemicals (xenobiotics) during their passage through the body and as such encompass the kinetics of absorption, distribution, biotransformation/metabolism and excretion (ADME). It can simply be described as how the body handles xenobiotics. Pharmacokinetics uses mathematical equations (models) to describe the time course of ADME of xenobiotics in the body enabling us to better understand, interpret and even predict the nature and the extent of the biological effects (therapeutic or toxic) of xenobiotics,The journal is devoted to illustrating the importance of pharmacokinetics, pharmacodynamics, and pharmacometrics in drug development, clinical care, and the understanding of drug action. The journal publishes on a variety of topics related to pharmacometrics, including, but not limited to, clinical, experimental, and theoretical papers examining the kinetics of drug disposition and effects of drug action in humans, animals, in vitro, or in silico; modeling and simulation methodology, including optimal design; precision medicine; systems pharmacology; and mathematical pharmacology (including computational biology, bioengineering, and biophysics related to pharmacology, pharmacokinetics, orpharmacodynamics). Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome. The journal actively invites and promotes up-and-coming areas of pharmacometric research, such as real-world evidence, quality of life analyses, and artificial intelligence.