From a pharmacochemical viewpoint the ebb and flow adversary of leprotics too as could be commonplace developments in the chemotherapy of illness are inspected. Of the essential enemy of leprotics, which are used nowadays — dapsone, rifampicin, clofazimine, isoniazide, ethionamide and prothionamide — the bit of advancement, the central issues in their application and expected results to make improved collections are surveyed. Considering the science of Mycobacterium leprae, the target structures for new enemy of leprotics are seen. These structures consolidate the cell divider, the catabolism of open oxygen species, the ingestion frameworks of carbon sources, the amino perilous assimilation and the take-up of iron. Two potential new lead structures from various fields, 4-quinolones and mycobacterial ribonucleotide reductase inhibitors are presented.