Traumatology, Post-Operative Pain, Hypnosis and creates a platform for the authors to contribute towards the journal and the editorial office promises to peer review the submitted manuscripts to ensure quality. Chronic pain is any pain that lasts for more than three months. Chronic pain may arise from an initial injury, such as a back sprain, or there may be an ongoing cause, such as illness. Other health problems, such as fatigue, sleep disturbance, decreased appetite, and mood changes, often accompany chronic pain. Chronic pain may limit a person’s movements, which can reduce flexibility, strength, and stamina.Low back pain is considered to be chronic if it has been present for longer than three months. The type of pain may vary greatly and may be felt as bone pain, nerve pain or muscle pain. For instance, pain may be aching, burning, stabbing or tingling, sharp or dull, and well-defined or vague. The intensity may range from mild to severe. Pain killers are powerful drugs that interfere with the nervous system’s transmission of the nerve signals we perceive as pain. Most painkillers also stimulate portions of the brain associated with pleasure. The most powerful prescription painkillers are called opioids, which are opium-like compounds. They are manufactured to react on the nervous system in the same way as drugs derived from the opium poppy, like heroin. The most commonly abused opioid painkillers include oxycodone, hydrocodone, meperidine, hydromorphone and propoxyphene. Each person may also have a slightly different response to a pain reliever. Chronic Pain Chronic pain has the active pain for more than six months unlike acute pain. Chronic pain can be mild or excruciating, episodic or continuous, merely inconvenient or totally incapacitating. Chronic pain describes pain that lasts more than three to six months, or beyond the point of tissue healing. Chronic pain is usually less directly related to identifiable tissue damage and structural problems. There are at least two different types of chronic pain problems - chronic pain due to an identifiable pain generator (e.g. an injury), and chronic pain with no identifiable pain generator (e.g. the injury has healed) often termed “chronic benign pain”. Chronic pain and depression are two of the most common health problems that health professionals encounter. The type of depression with chronic pain is referred to as major depression or clinical depression. Nociceptive pain is caused by damage to body tissue and usually described as a sharp, aching, or throbbing pain. Nociceptive pain is due to benign or by tumors or by cancer cells that are growing larger and gathering other body parts at the cancer site. Nociceptive pain may also be caused by cancer spreading to the bones, muscles, or joints, or that causes the blockage of an organ or blood vessels. Nociceptive pain can be due to benign pathology; or by tumors or cancer cells that are growing larger and crowding other body parts near the cancer site. Nociceptive pain may also be caused by cancer spreading to the bones, muscles, or joints, or that causes the blockage of an organ or blood vessels. When nociceptors are stimulated they transmit signals through sensory neurons in the spinal cord. These neurons release the excitatory neurotransmitter glutamate at their synapses. Nociceptive pain is caused by damage to body tissue and usually described as a sharp, aching, or throbbing pain. Nociception can also cause generalized autonomic responses before or without reaching consciousness, hypertension, diaphoresis, cause pallor, tachycardia , nausea, light-headedness and fainting.