Another study showed that rice bran glycoprotein was able to help cyclophosphamide-treated mice recover from immunosuppression by promoting the proliferation of splenic lymphocytes.These reports indicate the immunomodulatory effects of rice bran in enhancing mucosal and systemic immunity. In gnotobiotic (Gn) pigs, rice bran intake exhibited high protective efficacy against diarrhea induced by human rotavirus (HRV) and norovirus,the two most prevalent viral pathogens causing gastroenteritis. In human clinical trials, dietary rice bran ameliorated type 2 diabetes by lowering lipid and glycemic levels, and arabinoxylan rice bran has been evaluated with promising therapeutic effects on irritable bowel syndrome (IBS) and chronic hepatitis C virus infection.In addition, emerging scientific evidence indicates that dietary rice bran represents chemopreventive potential against several types of cancer such as liver, lung, breast, and colon cancer.Overall, rice bran is being recognized as an economical, natural, novel, and safe dietary supplement with broad beneficial effects on animal and human health, including treating gastrointestinal diseases.