In order to increase the yield of the product and to maintain the product quality consistently, key issues of process optimization, industrial fermentation and scale-up studies are targeted at maintaining a set of homogenous conditions that reduces and minimizes the microbial risk towards stress and enhance their productivity by improving their metabolic accuracy. For every individual product, the set of process parameters that influence the yield and quality of the product will change. Those set of process parameters might be a single parameter or in combination with other parameter or many individual parameters and those parameters need to be identified and need to be optimized accordingly to the microbe used and product formed.