Some of the review articles provide an evaluation on drug use and abuse, its effect on life and also treatment of various harmful effects of alcohol. A major goal of research on drug and alcohol is to understand the main points associated with the transition state from drug use to drug dependence. These are international peer reviewed open access journals. Journal of Alcoholism, Drug Abuse and Substance Dependence (ISSN: 2572-9594) is an international peer-reviewed online open-access Journal with the perspective to present the new treatment methods and cure for alcohol and drug addicts. Alcoholism, drug abuse and substance dependence are pervasive international problems that severely affect the physical and mental health of the individuals who have them, their families, especially the vulnerable children who are at the risk of developing physical and mental health problems, whereas substance abuse is because of their parent's addictions. In contrast to the magnitude of the problem, research and practice address these issues.