Only 1% to 5% of HIV patients who develop a direct complications following. HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. It is a rare association, here we report the case of a woman of 69 years immunocompromised who Stroke diagnosed without another etiology found despite an etiologic assessment of the most common causes in our context. The patient had received treatment with an overall favorable evolution. Before a stroke recurrent of unknown etiology should think of HIV as this will allow appropriate treatment. The mechanism can be related with syphilis (Vasculitis) or by direct action of the virus on the central nervous system. HIV develop stroke in clinical series, although a higher proportion (4-34%) have cerebral lesions at autopsy public health . HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism and coagulopathy This association of HIV and STROKE is rare, we report here a case of recurrence of STROKE associated with HIV.