Different Signalling molecules, especially different peptides are the key modulators in various metabolic disorders, including obesity. Their expression at the cellular level changes the disease prognosis.The aim of present review is to enlist them all, and mention their significance in obesity, which helps researchers in drug discovery and future medicine.The last 20 years data has been searched and studied to mention their current role in obesity treatment and ailments of disease.This article stated the importance of various peptides, tissues and mast cells with their significance in relation to obesity. Authors also enlisted their role in other metabolic disorders because these complications are associated with obesity. This article will help researchers to explore the potential of mentioned peptides in drug discovery to cure metabolic disorders.especially different peptides are the key modulators in various metabolic disorders, including obesity. Their expression at the cellular level changes the disease prognosis.