Obesity-associated health conditions include heart disease, stroke, diabetes, musculoskeletal disorders, and cancers such as endometrial, breast, and colon. Obesity is also associated with all-cause mortality. The high prevalence of overweight and obesity continues to pose major public health challenges both globally and in the United States, particularly in Mississippi. In 2014, more than 1.9 billion adults worldwide were overweight and more than 600 million were obese. In the United States, data from the 2011 through 2012 National Health and Nutrition Examination Survey indicate that 78.6 million US adults (34.9%) were obese. Nationally, the annual cost of medical care related to obesity is estimated at $147 billion to $210 billion . In Mississippi, about 1.5 million adults (71.3%) were overweight or obese in 2015 , although rates varied by race and sex . A study of obesity trends in the Mississippi Delta Region (a region with a disproportionately high burden of cardiovascular disease and a population that is 50% black) found that the prevalence of obesity increased significantly, 3.5% annually from 2001 to 2010. The cost of obesity-related health care in Mississippi is projected to reach $3.9 billion by 2018 .