Animals were randomly assigned to five groups: a negative control (G1; n=10) that consumed a standard diet and 0.9% saline;a positive control with metabolic syndrome (G2; n=10) that consumed 66% w/w high-fructose diet and received saline solution similar to control; probiotic (G3; n=10) that consumed 66% w/w high-fructose diet supplemented with fermented milk containing Lactobacillus plantarum Lp115 (109 CFU/ml per day); prebiotic (G4; n=10) that consumed 66% w/w high-fructose diet supplemented with Giroil® yacon powder (10%) reconstituted in water, providing 0,041g/FOS/ml(1011 CFU/ml day), and symbiotic (G5; n=10) that consumed 66% w/w high-fructose diet supplemented with symbiotic drink containing Lactobacillus plantarum (Lp115) and yacon (10%). All diets were administeredby oral gavage for eight weeks. Animals had free access to water and food with or without fructose. All variables were measured at baseline and after 8 weeks.