The effectiveness of BD was also shown in neuropathic pain, a representative of complex regional pain syndrome (CRPS.) Neuropathic pain was induced after the nerve root injury, and the bone is generally intact. However, BD alleviates a foot ache that is produced thereafter. This fact may indicate that subsequent medullary inflammation occurs and bone tissue is involved in CRPS. Therefore, a certain change within the bone is induced by CRPS. The fact suggests a hypothesis that a self-facilitating mechanism of pain is provided independently within bone marrow. Sumihisa Aida, Pain Relief by Bone Drilling and Osseous Pain Sensitization