The nervous and immune system are in constant dialogue, but information of that how these two necessary systems are integrated and functionally co-operative together at the molecular level are only now being advertised. Much of the current research in this field has highlighted on the role of immune cells and immune mediators in the initialization and the progression of specific neurological disorders such as multiple sclerosis or AlzheimerÂ’s disease. But how do autoimmune T-cells entered into the brain and how they contribute to neurological disorders? Can serum antibodies affect brain functioning? Such questions are still under research process. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information.