Neurogenic hypertension is presumably to occur in patients with labile or paroxysmal hypertension, but evidence of increased sympathetic tone also suggests a neurogenic component in hypertension in patients with severe or resistant hypertension, chronic renal disease, comorbidities related to increased sympathetic tone, and ingestion of medicine that stimulate sympathetic tone.The importance of combined alpha- and beta-blockade in pharmacologic treatment and the status of renal denervation are discussed.