Initially newborns have no abnormalities but later stages due to less accumulation of mucopolysaccharides the symptoms will starts. In this disorders the physical appearance of baby changes with this defect. These can be treated initially in the neonatal nursing period. In this period the newborns should treat with the specific enzymes and also some times it needs bone marrow transplantation. Scholarly peer review is the process of subjecting an author's scholarly work, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal. The work may be accepted, considered acceptable with revisions, or rejected. Peer review requires a community of experts in a given (narrowly defined) field, who are qualified and able to perform reasonably impartial review