Pancreatic malignancy is a forceful and obliterating illness representing 44,000 new cases for every year in US. It is described by obtrusiveness, fast movement and significant protection from treatment. Most of cases are determined above age 65 to have about 60% of cases at a propelled stage and multi year endurance under 10%. Advances in sub-atomic science have incredibly improved our comprehension of pathogenesis of pancreatic disease. Numerous patients have changes of K-ras oncogene and different tumor silencer qualities are additionally researched. Radical medical procedure remains the main corrective treatment choice for pancreatic disease in beginning times. For privately progressed, unresectable and metastatic infection, treatment is palliative, in type of adjuvant or neoadjuvant chemotherapy with or without radiotherapy. Gemcitabine based mixes have basically neglected to give a significant prolongation of endurance and comprise treatment choice just in patients with a decent exhibition status. This article gives a review of the study of disease transmission, dangers factors, atomic hereditary qualities, biomarkers, symptomatic methodology and proof based remedial choices for resectable and palliative alternatives for unresectable sickness.