Metabolic Disorder Scholarly Peer-review Journal

Metabolic Disorder Scholarly Peer-review Journal

.The conference offered a unique opportunity to investigators across the globe in order to meet, explore, network and perceive new scientific innovations. The conference received commendable and active participation was received from the Editorial Board Members of PrimeOA Publications Journals as well as from the global scientists, Professors, Academicians, Researcher Scholars and students  from  diverse fields of Diabetes & Endocrinology. In this study, to evaluate the role of IR isoforms in cell growth and differentiation via IRS-3, a recognized mediator of cell differentiation, we co-transfected 32D murine hemopoietic cells with IRS-3 and either IR-A or IR-B. Both isoforms, when activated by insulin, were able to activate cell growth and differentiation programs even in the absence of IL-3, an absolute requirement for 32D cell survival. IR-B was much more effective than IR-A for both functions. IGF-2, although activating IR-A as expected, was not able to stimulate growth via IRS-3 and only minimally differentiation. Finally, to stimulate growth via IRS-3 insulin required for both isoforms the activation of both the ERK and the p70S6K pathways, while to stimulate differentiation the activation of only one pathway was required. In conclusion, via IRS-3, IR-B is much more active than IR-A and IGF-2 has no biological effect even when activating IR-A.To encourage Women scientists and researchers by providing a platform where they can present their work and passion towards their research Women Scientist Award will be presented which is also termed as The Women of Science Award. To acknowledge the speakers with great presentation skills, influential research work and long term excellence Outstanding Speaker Award will be presented. Best Keynote Speaker Award will be presented to the keynote speaker who adds an extraordinary feel to the conference by their distinguished research work, projects and strategies that will provide a new trend in the field of Industrial Chemistry and Aqua Technology.


Last Updated on: Nov 28, 2024

Global Scientific Words in Medical Sciences