Marfan syndrome is one among the foremost common single gene abnormalities. Antoine Marfan had described it in 118 years ago, the syndrome has shown remarkable pleiotropisms because it's being recognized more widely in “asymptomatic” individuals. Seventy to eighty percent of affected individuals develop aortic root dilatation and somewhat fewer patients develop mitral and aortic valve abnormalities, which account for the gravest manifestations of this connective tissue disease.