Malaria is a mosquito-borne infection that affects humans and other animals. It causes symptoms that typically include fever, tiredness, vomiting, and headaches. The severity of malaria varies based on the species of plasmodium. Symptoms are chills, fever and sweating, usually occurring a few weeks after mosquitoe bite. The malaria parasite life cycle involves two hosts. During a blood meal, a malaria-infected female Anopheles mosquito inoculates sporozoites into the human host Malaria is a disease that is spread by the female Anopheles mosquito. There are two types of malaria: uncomplicated and severe malaria. Malaria is a potentially life-threatening disease caused by infection with Plasmodium protozoa transmitted by an infective female Anopheles. The infection can result from any one of five parasites from the Plasmodium group including (P. flaciparum), (P. vivax), (P. ovale), (P. malariae), and (P. knowlesi). Malaria causes fever, chills, malaise, headaches, and myalgia and can result in death if not treated appropriately. Hydroxychloroquine is the most important drug used against malaria. An estimated 50% of the world’s population, about 3.3 billion people, are at risk for Malaria. The following areas are most commonly affected by malaria : Africa, India, Pakistan, Southeast Asia, Paupa New Guinea, Haiti, and parts of South America.