Mangiferin is a nutraceutical, a polyphenolic ingredient extracted from the stem bark and leaves of Mango tree (Mangifera indica L.), a tropical fruit-bearing plant, with a spate of purported beneficial health effects. It is widely used in Latin America and the Caribbean region for protection against chronic disorders and treatment of acute ailments. Reported benefits of mangiferin range from antioxidant, antiinfectious, antidiabetic, antiatherosclerotic, and cardiovascular effects to enhanced cognitive brain function. Mangiferin shows exceptional antioxidant activity, stronger than cinnamon, and hepatoprotective activity against free radical-induced liver injury in the mouse in vivo.