The Journal of Information Technology & Software Engineering is an academic journal – a pioneer in open access publishing–and is listed among the top 10 journals in Information Technology. Software engineering is the application of a systematic, disciplined, quantifiable approach to the development, operation, and maintenance of software. Information technology deals with the use of computers and telecommunications to store retrieve and transmit information. The journal addresses the latest advancements in the field of information technology & software engineering. Although additive approaches are used with a certain degree of success in a medical context, they often suffer from an inability to conveniently represent dependencies, which is certainly desirable in practice. To address this drawback, we present the concepts of non-additive measures, and non-additive integration, as well as Shapley values and interaction indices to a clinical framework, and show how they can be used to develop robust and reliable computing tools that support informed and shared decision-making. We also present an extension of these tools that allow us to manage the inherent uncertainty and imprecision of data, and help us address value clarification. To set ideas, we focus on presenting algorithms to improve shared decision-making for colorectal cancer screening, however, the framework presented here is general, and can be applied to a wide variety of clinical decision problems.